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BIIB 021, Tocris Bioscience™

Catalog No. 460810
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Catalog No. Quantity
46-081-0 10 mg
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Catalog No. 46-081-0 Supplier R&D Systems Supplier No. 4608/10
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Description

Selective Hsp90 inhibitor

Selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.

Chemical Identifiers

CAS 848695-25-0
Molecular Formula C14H15ClN6O
Molecular Weight (g/mol) 318.765
InChI Key QULDDKSCVCJTPV-UHFFFAOYSA-N
PubChem CID 16736529
IUPAC Name 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]purin-2-amine
SMILES CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N

Specifications

Quantity 10 mg
Synonym biib021, 6-chloro-9-4-methoxy-3,5-dimethylpyridin-2-yl methyl-9h-purin-2-amine, biib 021, biib-021, unii-851b9fq7q0, 6-chloro-9-4-methoxy-3,5-dimethylpyridin-2-yl methyl purin-2-amine, 6-chloro-9-4-methoxy-3,5-dimethyl-2-pyridinyl methyl-9h-purin-2-amine, 3qdd
Formula Weight 318.76
Percent Purity >98%
Chemical Name or Material BIIB 021

Safety and Handling

Recommended Storage Store at -20°C
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