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BIIB 021, Tocris Bioscience™
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Quantity:
10 mg
Description
Selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.
Specifications
Specifications
Quantity | 10 mg |
Synonym | biib021, 6-chloro-9-4-methoxy-3,5-dimethylpyridin-2-yl methyl-9h-purin-2-amine, biib 021, biib-021, unii-851b9fq7q0, 6-chloro-9-4-methoxy-3,5-dimethylpyridin-2-yl methyl purin-2-amine, 6-chloro-9-4-methoxy-3,5-dimethyl-2-pyridinyl methyl-9h-purin-2-amine, 3qdd |
Formula Weight | 318.76 |
Percent Purity | >98% |
Chemical Name or Material | BIIB 021 |
Safety and Handling
Recommended Storage | Store at -20°C |
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