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  5. Tocris Bioscience™ BIRT 377

Tocris Bioscience™ BIRT 377
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Catalog No. p-5545713
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Catalog No. Quantity
47-761-0 10 mg
47-765-0 50 mg
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Catalog No. 47-761-0 Supplier Tocris Bioscience™ Supplier No. 4776/10
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Description

Potent negative allosteric modulator of LFA-1

BIRT 377 is a potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM). BIRT 377 binds to the I-domain of LFA-1. BIRT 377 reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. BIRT 377 inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo. Orally available.

Specifications

Quantity 10 mg
Product Type BIRT 377
Purity >98%
Molecular Weight (g/mol) 442.13
Inhibitors BIRT 377

For Research Use Only

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