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Tocris Bioscience™ BIRT 377

Potent negative allosteric modulator of LFA-1

$328.28 - $1367.64

Specifications

Purity >98%
Product Type BIRT 377
Molecular Weight (g/mol) 442.13
Inhibitors BIRT 377
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
47-761-0
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Tocris Bioscience™
4776/10 		10 mg
Each for $328.28
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47-765-0
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Tocris Bioscience™
4776/50 		50 mg
Each for $1,367.64
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Description

Description

Potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM). Binds to the I-domain of LFA-1. Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. Inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo. Orally available.
Specifications

Specifications

>98%
BIRT 377
442.13
BIRT 377
SDS
Documents

Documents

Product Certifications

For Research Use Only

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