Bleomycin Sulfate, PROMO, Thermo Scientific Chemicals

Description

Bleomycin sulfate is a glycopeptide compound with antibiotic activity isolated from Streptomyces verticillus. It also exhibits anticancer activity.

General Description

• Bleomycin sulfate was initially isolated from Streptomyces verticillus. It is a glycopeptide compound with antibiotic activity
• It has the ability to induce oxidative cleavage of the DNA backbone, leading to apoptosis
• Bleomycin sulfate can form a complex with iron that reduces oxygen to superoxide and hydroxyl radicals. These reactive oxygen species can cause single- and double-stranded breaks in DNA as well as promote carbohydrate oxidation, lipid peroxidation, and alterations in prostaglandin synthesis and degradation

Application

• It can be used to inhibit DNA metabolism and slow or stop cell growth. This property explains its anticancer activity
• Bleomycin sulfate can also be used to degrade RNA as it is more selective to RNA than DNA
• Local injections of bleomycin sulfate in mouse models can induce sclerotic skin mimicking scleroderma
• In laboratory research, bleomycin is used to induce pulmonary fibrosis in mice

Specifications

Chemical Identifiers

• CAS: 9041-93-4
• Molecular Formula: C55H85N17O25S4
• Molecular Weight (g/mol): 1512.62 g/mol
• MDL Number: MFCD00070310
• InChI Key: WUIABRMSWOKTOF-UHFFFAOYSA-N
• PubChem CID: 131664136
• IUPAC Name: [2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[5-[[1-[2-[4-[4-(3-dimethylsulfoniopropylcarbamoyl)-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hyd
• SMILES: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=N)[O-])O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)O

• Type: Bleomycin Sulfate
• Physical Form: Powder
• Color: White
• Quantity: 10 mg
• Merck Index: 14,1318
• Solubility Information: Soluble in water or DMSO
• Chemical Name or Material: Bleomycin sulfate

Safety and Handling

EINECSNumber	232-925-2
RTECSNumber	EC5991990
TSCA	No
storageNote1	2° to 8°C
Recommended Storage	Keep cold

RUO - Research Use Only