Tocris BMS 345541
Selective allosteric inhibitor of IKK; anti-inflammatory
Manufacturer: Tocris 4806/10
DescriptionSelective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0µM for IKKβ and IKKα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.
- Chemical Name: N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride
- Formula: C14H17N5.HCl
- CAS Number: 547757-23-3
- Solubility: Soluble to 100mM in water and to 100mM in DMSO
- Purity: >99
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