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Tocris Bioscience™ BRD 0539
Cell permeable and reversible Cas9 inhibitor
$238.96 - $998.76
Specifications
| Chemical Name or Material | (3 aR,4 R,9 bR)-8-(2-Fluorophenyl)-2,3,3 A,4,5,9 b-hexahydro-1-[(4-methylphenyl)sulfonyl]-1 H-pyrrolo[3,2-c]quinoline-4-methanol |
|---|---|
| CAS | 1403838-79-8 |
| Target | CRISPR Reagents |
| Molecular Formula | C25H25FN2O3S |
| Purity | 0.98 |
Description
BRD 0539 is a cell-permeable and reversible SpCas9 (Streptococcus pyogenes Cas9) inhibitor. BRD 0539 shows dose-dependent SpCas9 inhibition in an in vitro DNA cleavage assay (apparent IC50 = 22 μM) and in an eGFP disruption assay (apparent EC50 = 11 μM). Allows dose and temporal control of SpCas9-based systems.Specifications
| (3 aR,4 R,9 bR)-8-(2-Fluorophenyl)-2,3,3 A,4,5,9 b-hexahydro-1-[(4-methylphenyl)sulfonyl]-1 H-pyrrolo[3,2-c]quinoline-4-methanol | |
| CRISPR Reagents | |
| 0.98 |
| 1403838-79-8 | |
| C25H25FN2O3S |
Safety and Handling
Recommended Storage : Store at -20°C
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