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  5. Tocris Bioscience™ BRD 0539

Tocris Bioscience™ BRD 0539
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Catalog No. p-7237086
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Quantity:
2 mg
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Cell permeable and reversible Cas9 inhibitor

BRD 0539 is a cell-permeable and reversible SpCas9 (Streptococcus pyogenes Cas9) inhibitor. BRD 0539 shows dose-dependent SpCas9 inhibition in an in vitro DNA cleavage assay (apparent IC50 = 22 μM) and in an eGFP disruption assay (apparent EC50 = 11 μM). Allows dose and temporal control of SpCas9-based systems.

Specifications

Chemical Name or Material (3 aR,4 R,9 bR)-8-(2-Fluorophenyl)-2,3,3 A,4,5,9 b-hexahydro-1-[(4-methylphenyl)sulfonyl]-1 H-pyrrolo[3,2-c]quinoline-4-methanol
CAS 1403838-79-8
Quantity 10 mg
Target CRISPR Reagents
Molecular Formula C25H25FN2O3S
Purity 0.98
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