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Thermo Scientific™ BSTFA Silylation Reagent

Obtain excellent GC separations with Thermo Scientific™ BSTFA Silylation Reagent.

Manufacturer:  Thermo Scientific™ TS38828

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Catalog No. PI38828

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Improve GC analysis with Thermo Scientific™ BSTFA Silylation Reagent. The highly volatile byproducts mono(trimethylsilyl)trifluoroacetamide (BSTFA) and trifluoroacetamide elute with the solvent front to ensure excellent chromatographic separations. This silylation reagent reacts with a wide range of polar compounds and is particularly well suited for the GC analyses of some lower boiling TMS-amino acids and TMS Krebs cycle acids.

BSTFA is a powerful thrimethylsilyl donor, with donor strength that is comparable to its unfluorinated analog BSA [N,O-Bis(trimethylsilyl)acetamide]. BSTFA reacts to replace labile hydrogens on a wide range of polar compounds with a -Si(CH3)3 group. This physical characteristic is particularly useful in the gas chromatography of some lower boiling TMS-amino acids and TMS Krebs cycle acids.
  • Increased volatility of reaction byproducts mono(trimethylsilyl)trifluoroacetamide and trifluoroacetamide over corresponding nonfluorinated compounds from BSA
  • Increased volatility makes it possible to derivatize smaller molecules with which the TMS derivatives elute with the byproducts from BSA


2°C to 8°C
25 g
98 to 100%
Trimethylsilyl 2,2,2-trifluoro-N-(trimethylsilyl)acetimidate
25 g
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