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Invitrogen™ Bub1 Monoclonal Antibody (A6E10)
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Catalog No. PIMA542550
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100 μL
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PIMA542550 100 μL
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Catalog No. PIMA542550 Supplier Invitrogen™ Supplier No. MA542550
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Description

Mouse Monoclonal Antibody

Positive Control: Hela cell lysate, K562 cell lysate, 293T cell lysate. Subcellular Location: Nucleus, kinetochore.

The BUB1 gene encodes a serine/threonine-protein kinase that is integral to the spindle assembly checkpoint, a crucial mechanism ensuring proper chromosome alignment and segregation during mitosis. BUB1 is involved in detecting and correcting errors in kinetochore-microtubule attachments, which is vital for maintaining genomic stability. It acts by delaying the onset of anaphase until all chromosomes are correctly attached to the spindle apparatus. BUB1 is recruited to kinetochores in early mitosis, where it phosphorylates several substrates to activate other checkpoint proteins, such as BUBR1 and MAD2, thereby preventing premature progression through mitosis. Mutations or aberrations in the expression levels of BUB1 are often associated with aneuploidy and chromosomal instability, contributing to cancer progression. BUB1 is thus considered a potential target for cancer therapeutics, aiming to exploit its role in the mitotic checkpoint to selectively eliminate tumor cells through checkpoint bypass or mitotic arrest.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bub1
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone A6E10
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol, 0.05% BSA and 0.05% sodium azide; pH 7.4
Gene BUB1
Gene Accession No. O43683
Gene Alias Aamp; Aamp-rs; AL022991; angio associated migratory cell protein; angio-associated migratory cell protein; angio-associated migratory protein; angio-associated, migratory cell protein; AU040907; BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog; BUB1 mitotic checkpoint serine/threonine kinase; BUB1, mitotic checkpoint serine/threonine kinase; BUB1A; BUB1L; budding uninhibited by benzimidazoles 1 homolog; budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae); C80208; D2Xrf87; hBUB1; mBUB1; mitotic checkpoint serine/threonine-protein kinase BUB1; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase
Gene Symbols BUB1
Host Species Mouse
Immunogen Recombinant protein within human Bub1 aa 1-200.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 699
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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