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Tocris Bioscience™ BX 471
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Catalog No. 349610
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Quantity:
10 mg
50 mg
Catalog No. Quantity
34-961-0 10 mg
34-965-0 50 mg
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Catalog No. 34-961-0

Supplier: Tocris Bioscience™ 3496/10

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Description

Potent, selective CCR1 antagonist

Potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP-α/CCL3-induced intracellular Ca2+ mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.

Chemical Identifiers

CAS 217645-70-0
Molecular Formula C21H24ClFN4O3

Specifications

Quantity 10 mg
Formula Weight 434.89
Purity >98%
Molecular Weight (g/mol) 434.896
Chemical Name or Material BX 471

Safety and Handling

Recommended Storage Store at +4°C
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