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Tocris Bioscience™ BX 471
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Quantity:
10 mg
50 mg
Description
Potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP-α/CCL3-induced intracellular Ca2+ mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.
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Specifications
Specifications
| Quantity | 50 mg |
| Formula Weight | 434.89 |
| Purity | >98% |
| Chemical Name or Material | BX 471 |
Safety and Handling
| Recommended Storage | Store at +4°C |
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