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  5. Tocris Bioscience™ Bz 423

Tocris Bioscience™ Bz 423
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Catalog No. 579110
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

ATP synthase inhibitor; proapoptotic

Bz 423 is an ATP synthase inhibitor (IC50 ~5 μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model.

Specifications

Chemical Name or Material 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
CAS 216691-95-1
Quantity 10 mg
Solubility Soluble to 100mM in DMSO and to 100mM in ethanol
Molecular Formula C27H21ClN2O2
Formula Weight 440.92
Physical Form Solid
Color White
Product Type Bioactive Small Molecule
Purity >98%

For Research Use Only.

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