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CA19-9/Sialyl Lewis A Antibody (SPM588) - IHC-Prediluted, Novus Biologicals™
SDP

Catalog No. NBP248432 Shop All R&D Systems Products
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NBP248432 7 mL
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Catalog No. NBP248432 Supplier Novus Biologicals Supplier No. NBP248432
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Description

Mouse Monoclonal Antibody

CA19-9/Sialyl Lewis A Monoclonal specifically detects CA19-9/Sialyl Lewis A in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen CA19-9/Sialyl Lewisa
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone SPM588
Conjugate Unconjugated
Dilution Immunohistochemistry-Paraffin
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Host Species Mouse
Immunogen Precipitin lines obtained after immuno-diffusion using MAb 116-NS-19-9 and mucins isolated from an ovarian cyst of a Lewis A+B- patient (0Le).
Purification Method Protein L or PEG purified
Quantity 7 mL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity CA19-9, a carbohydrate epitope expressed on a high MW (400kDa) mucin glycoprotein, is a sialyl Lewisa structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewisa and/or Lewisb blood group antigens. In normal tissues, sialyl Lewisa antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas. Preoperative elevated CA19-9 levels in patients with stage I pancreatic carcinoma decrease to normal values following surgery. When used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings. This monoclonal antibody is superb for staining of formalin-fixed, paraffin-embedded tissues.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgM κ
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