Epredia™ Lab Vision™ Cadherin-P Ab-1, Mouse Monoclonal Antibody

Obtain accurate, reproducible results in immunohistochemistry experiments with Epredia™ Cadherin-P Ab-1, Mouse Monoclonal Antibody.

Supplier:  Epredia™ MS1741S0

Catalog No. MS1741S0

Description

Cadherins are calcium dependent cell adhesion molecules, which play important roles in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. They are expressed in a tissue specific manner and are required for assembly of cells into solid tissue. Individual cadherin molecules are known to cooperate with each other to form a linear cell adhesion zipper. In adhesion junctions cadherins are bound to Beta and gamma catenins which in turn bind to alpha catenin, an actin binding protein. Cadherins play important part in tumor invasion and metastasis. P-cadherin is selectively expressed in basal and parabasal layers of stratified epithelia. It may be involved in the final stages of tumor progression in epidermal carcinoma. Changes in P-cadherin expression have been implicated in breast and melanocytic tumors.

Host Species: Mouse

Clone: 56C1

Isotype: IgG1

Species Reactivity: Human. Others not known.

Epitope: External domain

Immunogen: Recombinant protein corresponding to extracellular domain of human cadherin-P

Molecular Weight: 120kDa

Positive Control: Skin

Cellular Localization: Membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)

Note:

USA: IVD; Int'l: IVD

Specifications

• Antigen: Cadherin-P/P-cadherin Ab-1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Immunogen: Recombinant protein corresponding to extracellular domain of human P-cadherin
• Quantity: 100 μL
• Research Discipline: Junction Protein
• Target Species: Human
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin)
• Clone: 56C1
• Host Species: Mouse
• Purification Method: Skin
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Supernatant