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  5. 5057340001

MilliporeSigma™ Calbiochem™ BzATP Triethylammonium Salt

Catalog No. 5057340001
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Quantity:
1 mg

Description

A prototypic P2X7 purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC50 = 15μM vs

A prototypic P2X7 purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC50 = 15μM vs 50μM). Serves as a photo-affinity analog of ATP. Its agonistic activity is significantly reduced in the presence of serum albumin. Can serve as a substrate analog for submitochondrial particle ATPase activity (Km = 940μM). Induces a dose-dependent decrease in wild-type murine neural progenitor cell viability and an increase in caspase-3 activity. These effects are not observed in P2X7-/- mice.
TRUSTED_SUSTAINABILITY

Specifications

Quantity 1 mg
Solubility H2O
Molecular Formula C24H24N5O15P3·3C6H15N
Physical Form Solid
Color White
Purity 98% by HPLC
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