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MilliporeSigma™ Calbiochem™ BzATP Triethylammonium Salt
A prototypic P2X7 purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC50 = 15μM vs
Supplier: MilliporeSigma™ 5.05734.0001
Description
A prototypic P2X7 purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC50 = 15μM vs 50μM). Serves as a photo-affinity analog of ATP. Its agonistic activity is significantly reduced in the presence of serum albumin. Can serve as a substrate analog for submitochondrial particle ATPase activity (Km = 940μM). Induces a dose-dependent decrease in wild-type murine neural progenitor cell viability and an increase in caspase-3 activity. These effects are not observed in P2X7-/- mice.Specifications
| 1 mg | |
| C24H24N5O15P3·3C6H15N | |
| White |
| H2O | |
| Solid | |
| 98% by HPLC |
Safety and Handling
Recommended Storage : Protect from light
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