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  6. Calcipotriol, Tocris Bioscience™

Calcipotriol, Tocris Bioscience™

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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
112965-21-6
C27H40O3
412.61
MFCD10567086,MFCD10567086
LWQQLNNNIPYSNX-OUSHRDKSSA-N
calcipotriol calcipotriene
131954607
(1R,3S,5Z)-5-{2-[(1R,4E,7aR)-1-[(2R,3E,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
C[C@H](\C=C\[C@@H](O)C1CC1)[C@H]1CCC2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
This item is not returnable. View return policy
112965-21-6
C27H40O3
412.61
MFCD10567086,MFCD10567086
LWQQLNNNIPYSNX-OUSHRDKSSA-N
calcipotriol calcipotriene
131954607
(1R,3S,5Z)-5-{2-[(1R,4E,7aR)-1-[(2R,3E,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
C[C@H](\C=C\[C@@H](O)C1CC1)[C@H]1CCC2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C

Description

Vitamin D3 analog

Calcipotriol is a vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Calcipotriol suppresses skin cancer development in mice in a thymic stromal lymphopoietin (TSLP)-dependent manner. Calcipotriol promotes the differentiation of keratinocytes. In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells.
Quantity 50 mg
Formula Weight 412.6
Percent Purity >98%
Chemical Name or Material Calcipotriol

Safety and Handling

Recommended Storage : Desiccate at -20°C

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