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Caldesmon/CALD1 Antibody (CALD1/820 + h-CALD), DyLight 755, Novus Biologicals™
SDP

Catalog No. NBP247819IR Shop All R&D Systems Products
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NBP247819IR 0.1 mL
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Description

Mouse Monoclonal Antibody

Caldesmon/CALD1 Monoclonal specifically detects Caldesmon/CALD1 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Caldesmon/CALD1
Applications Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone CALD1/820 + h-CALD
Conjugate DyLight 755
Dilution Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias CAD, caldesmon, caldesmon 1, CDMH-CAD, HCAD, LCAD, L-CAD, MGC21352, NAG22
Gene Symbols CALD1
Host Species Mouse
Immunogen Recombinant full-length human Caldesmon/CALD1 protein (Caldesmon/CALD1/820); Crude human uterus extract (h-CALD) (Uniprot: Q05682)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Cytoskeleton Markers, Phospho Specific
Primary or Secondary Primary
Gene ID (Entrez) 800
Test Specificity Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon. Two closely related variants of human caldesmon have been identified which are different in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120'150kDa) is predominantly expressed in smooth muscle whereas l-caldesmon (70'80kDa) is found in non- muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. This monoclonal antibody recognizes only the 150kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction.
Target Species Human
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG1 κ
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