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CaMKIV Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. p-7205284 Shop All Proteintech Group Inc Products
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50-172-8611 150 μL
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Catalog No. 50-172-8611 Supplier Proteintech Group Inc Supplier No. 132631AP150UL
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Rabbit Polyclonal Antibody

CaM kinase IV (CaMKIV), in a calcium and calmodulin dependent manner, is implicated in phosphorylating numerous transcription factors including the CCAAT enhancer binding protein (C/EBP), serum response factor (SRF), and cyclic AMP response element binding protein (CBP). The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.

Specifications

Antigen CaMKIV
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CAMK4
Gene Accession No. P08414, P13234, Q16566
Gene Alias CaM kinase GR, CaMK GR, CAMK4, CaMKIV
Gene Symbols CAMK4
Host Species Rabbit
Immunogen CaMKIV Fusion Protein Ag3922
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12326, 25050, 814
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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