CAMLG Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 233271AP
DescriptionThe immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|calcium modulating ligand, CAML, CAMLG|
|12328, 81715, 819|
|Immunohistochemistry (Paraffin), Western Blot|
|CAMLG Fusion Protein Ag19915|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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