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Carbonic Anhydrase IX/CA9 Antibody (66.4.C2 (PN-15)), Janelia Fluor™ 549, Novus Biologicals™
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Catalog No. N233152J549 Shop All R&D Systems Products
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N233152J549 0.1 mL
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Catalog No. N233152J549 Supplier Novus Biologicals Supplier No. NBP233152JF549
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Description

Mouse Monoclonal Antibody

Carbonic Anhydrase IX/CA9 Monoclonal specifically detects Carbonic Anhydrase IX/CA9 in Human, Equine samples. It is validated for Immunohistochemistry-Paraffin.

Specifications

Antigen Carbonic Anhydrase IX/CA9
Applications ELISA, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 66.4.C2 (PN-15)
Conjugate Janelia Fluor 549
Dilution ELISA, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias CA-IX, CAIXcarbonic anhydrase 9, Carbonate dehydratase IX, carbonic anhydrase IXpMW1, carbonic dehydratase, EC 4.2.1.1, G250, Membrane antigen MN, MNRCC-associated antigen G250, P54/58N, RCC-associated protein G250, Renal cell carcinoma-associated antigen G250
Gene Symbols CA9
Host Species Mouse
Immunogen Fresh, normal human renal cortical tissue homogenate was used as immunogen to generate the RCC antibody.
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Dendritic Cell Markers, Ovarian Carcinoma Cell Markers, Renal Cell Carcinoma Cell Markers, Vision
Primary or Secondary Primary
Gene ID (Entrez) 768.0
Test Specificity Recognizes a glycoprotein of ∼200kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowmans capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This monoclonal antibody may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.
Target Species Human, Equine
Content And Storage Store at 4°C in the dark.
Isotype IgG2b κ
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