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CBLN4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 205591AP

Catalog No. 50-173-2961


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Description

Description

The antibody has no cross reaction to CBLN1, 2, or 3.

Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3) and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other ft.s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases.
Specifications

Specifications

CBLN4
0.19 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q8BME9, Q9NTU7
CBLN4, CBLNL1, Cerebellin 4, cerebellin 4 precursor, Cerebellin like glycoprotein 1
Rabbit
IgG
150 μL
-20°C
Primary
140689, 228942, 499947
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
CBLN4
Liquid
Cbln4
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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