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Invitrogen™ CBX4 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5110770
Description
Immunogen sequence: SPKYNTWEPE ENILDPRLLI AFQNRERQEQ LMGYRKRGPK PKPLVVQVPT FARRSNVLTG LQDSSTDNRA KLDSGAEEK.
Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.
Specifications
CBX4 | |
Polyclonal | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
O00257 | |
CBX4 | |
Recombinant Protein corresonding to Human CBX4. Recombinant protein control fragment (Product #RP-105723). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Immunocytochemistry | |
Unconjugated | |
CBX4 | |
Cbx4; chromobox 4; chromobox homolog 4; chromobox homolog 4 (Pc class homolog, Drosophila); chromobox protein homolog 4; chromobox-like protein 4; E3 SUMO-protein ligase CBX4; E3 SUMO-protein transferase CBX4; hPc2; MPc2; NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog; PC2; Polycomb 2 homolog | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
8535 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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