CCBE1 Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-4365	150 μL

Catalog No. 50-173-4365 Supplier Proteintech Group Inc Supplier No. 244491AP150UL

Description

Rabbit Polyclonal Antibody

The gene encoding CCBE1 (Collagen and calcium-binding EGF domain-containing protein 1) is located on chromosome 18 in a region that is frequently found to be deleted in breast and prostate cancers. CCBE1 is a 406 amino acid secreted protein that contains two collagen-like domains and one calcium-binding epidermal growth factor (EGF-like) domain. In general, EGF-like domains include six cysteine residues that are usually involved in disulfide bonds. Calcium-binding EGF-like domains are subject to amino acid substitutions that disrupt their structure or calcium affinity, therefore altering protein function. Downregulation of the gene encoding CCBE1 is observed with high frequency in breast cancer, suggesting that loss of CCBE1 results in changes in cell adhesion and mobility due to its characterization as an extracellular protein. There are three named isoforms of CCBE1 which are produced as a result of alternative splicing events.

Specifications

• Antigen: CCBE1
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.45 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: CCBE1
• Gene Accession No.: Q6UXH8
• Gene Alias: CCBE1, Full of fluid protein homolog, KIAA1983
• Gene Symbols: CCBE1
• Host Species: Rabbit
• Immunogen: CCBE1 Fusion Protein Ag19686
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 147372
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG