Invitrogen™ CCDC36 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561072

Catalog No. PIPA561072

Description

Immunogen sequence: GEFIEMKSNL KHLEVLVAQQ SQEFQQLCEQ LGQLNVPSVL AELKRLISVP PVKDSASQTS PPLAQSLNLT RQEKYTSEKP VLWQAQALPA AWNPGMGSLQ Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 61%.

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

Specifications

• Antigen: CCDC36
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCDC36
• Gene Alias: Cancer/testis antigen 74; Ccdc36; coiled-coil domain containing 36; coiled-coil domain-containing protein 36; CT74; IHO1; Interactor of HORMAD1 protein 1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 339834
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IYA8
• Gene Symbols: CCDC36
• Immunogen: Recombinant protein corresponding to Human CCDC36. Recombinant protein control fragment (Product #RP-100228).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG