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CCR5 Antibody (12D1), Alexa Fluor™ 350, Novus Biologicals™
SDP

Catalog No. NP24779A30 Shop All R&D Systems Products
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NP24779A30 0.1 mL
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Catalog No. NP24779A30 Supplier Novus Biologicals Supplier No. NBP247759AF350
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Description

Mouse Monoclonal Antibody

CCR5 Monoclonal specifically detects CCR5 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen, Immunofluorescence.

Specifications

Antigen CCR5
Applications Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen), Immunofluorescence
Classification Monoclonal
Clone 12D1
Conjugate Alexa Fluor 350
Dilution Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunofluorescence
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias C-C CKR-5, C-C motif chemokine receptor 5 A159A, CCCKR5, CC-CKR-5FLJ78003, CCR-5, CD195, CD195 antigen, chemokine (C-C motif) receptor 5, chemokine receptor CCR5, chemr13, CKR5, CKR-5, HIV-1 fusion coreceptor, IDDM22CMKBR5C-C chemokine receptor type 5
Gene Symbols CCR5
Host Species Mouse
Immunogen Human native CCR5 protein (Uniprot: P51681)
Quantity 0.1 mL
Primary or Secondary Primary
Gene ID (Entrez) 1234
Test Specificity Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG2a κ
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