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Invitrogen™ CD109 Monoclonal Antibody (HU17), eBioscience™, Invitrogen™

Catalog No. 14109937
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14-109-937 2 mg
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Catalog No. 14-109-937 Supplier Invitrogen™ Supplier No. 14109937
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Description

Mouse Monoclonal Antibody

The HU17 MAb reacts with human CD109, also known as the platelet-specific Gov antigen. CD109, a GPI-anchored monomeric glycoprotein, exists in two isoforms of 120 and 150 kDa, which are proteolytically degraded from a 170 kDa form. CD109 is expressed on activated T cells, activated platelets and endothelial cells. CD109 expression is also found on a subset of CD34+ cells in adult and fetal bone marrow which contain megakaryocyte, myeloid, erythroid and multilineage progenitors, as well as pluriopotent hematopoietic stem cells. Recently, it has been demonstrated that CD109 is expressed on a variety of human cancer cell lines, and also lung and esophogeal cell carcinomas. In addition, CD109 was recently found to be a negative regulator of TGF-beta in keratinocytes.

CD109 is a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta).
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD109
Applications Flow Cytometry, Immunoprecipitation
Classification Monoclonal
Clone HU17
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene CD109
Gene Accession No. Q6YHK3
Gene Alias 150 kDa TGF-beta-1-binding protein; 9930012E15Rik; activated T-cell marker CD109; AI480638; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; Cd109; CD109 antigen; CD109 molecule; CPAMD7; GARP; Gov platelet alloantigens; GPI-anchored alpha 2 macroglobulin-related protein; GPI-anchored alpha-2 macroglobulin-related protein; p180; platelet-specific Gov antigen; r150; RP11-525G3.1
Gene Symbols CD109
Host Species Mouse
Purification Method Affinity chromatography
Quantity 2 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 135228
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

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