Invitrogen™ CD109 Monoclonal Antibody (HU17), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 14109937

Catalog No. 14-109-937

Description

The HU17 MAb reacts with human CD109, also known as the platelet-specific Gov antigen. CD109, a GPI-anchored monomeric glycoprotein, exists in two isoforms of 120 and 150 kDa, which are proteolytically degraded from a 170 kDa form. CD109 is expressed on activated T cells, activated platelets and endothelial cells. CD109 expression is also found on a subset of CD34+ cells in adult and fetal bone marrow which contain megakaryocyte, myeloid, erythroid and multilineage progenitors, as well as pluriopotent hematopoietic stem cells. Recently, it has been demonstrated that CD109 is expressed on a variety of human cancer cell lines, and also lung and esophogeal cell carcinomas. In addition, CD109 was recently found to be a negative regulator of TGF-beta in keratinocytes.

CD109 is a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta).

Specifications

• Antigen: CD109
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q6YHK3
• Gene Symbols: CD109
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 135228
• Content And Storage: 4°C
• Form: Liquid

• Applications: Flow Cytometry, Immunoprecipitation
• Clone: HU17
• Conjugate: Unconjugated
• Gene: CD109
• Gene Alias: 150 kDa TGF-beta-1-binding protein; 9930012E15Rik; activated T-cell marker CD109; AI480638; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; Cd109; CD109 antigen; CD109 molecule; CPAMD7; GARP; Gov platelet alloantigens; GPI-anchored alpha 2 macroglobulin-related protein; GPI-anchored alpha-2 macroglobulin-related protein; p180; platelet-specific Gov antigen; r150; RP11-525G3.1
• Host Species: Mouse
• Quantity: 2 mg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

Safety and Handling

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