CD117 Mouse anti-Human, PE, Clone: YB5.B8, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB561682	BD Biosciences 561682	25 μg
BDB555714	BD Biosciences 555714	0.1 mg

Description

The YB5.B8 monoclonal antibody specifically binds to CD117. CD117, also known as c-Kit, is a 145 kDa cell-surface glycoprotein with tyrosine kinase activity. CD117 is present on hematopoietic progenitor cell subsets, thymocytes, mast cells, hepatocytes and histiocytes. CD117 serves as a cytokine receptor for steel factor (SLF), also known as stem cell factor (SCF) or mast cell growth factor (MGF). The interaction of c-Kit and SLF is crucial to hematopoiesis, mast cell differentiation, melanogenesis, and germ cell development. The ability of the YB5.B8 antibody to block the binding of c-Kit ligand is still controversial.

Specifications

• Antigen: CD117
• Concentration: 0.2mg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human
• Immunogen: Acute myelocytic leukemia blasts
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Clone: YB5.B8
• Applications: Flow Cytometry
• Conjugate: PE
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Isotype: IgG1 κ
• Purification Method: Affinity Purified
• Description: KIT; c-Kit; SCFR; PBT; Mast/stem cell growth factor receptor

For Research Use Only.