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Invitrogen™ CD137 Ligand (4-1BB Ligand) Recombinant Rabbit Monoclonal Antibody (BLR148J)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA544483
Description
CD137 Ligand (4-1BB Ligand) Recombinant Monoclonal Antibody for Western Blot
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.
Specifications
CD137 Ligand (4-1BB Ligand) | |
Recombinant Monoclonal | |
1000 μg/mL | |
PBS with 0.09% sodium azide; pH 6.8-7.4 | |
P41273 | |
TNFSF9 | |
Recombinant protein representing the extracellular domain of Human Tumor necrosis factor ligand superfamily member 9 (TNFSF9, aka 4-1BBL, CD137L; residues 71-254). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Western Blot | |
BLR148J | |
Unconjugated | |
TNFSF9 | |
4 1 BB Ligand; 4 1 BBL; 41BB Ligand; 4-1BB ligand; 41BBL; 4-1BBL; 4-1BB-L; AI848817; CD 137 Ligand; CD 137L; CD137 Ligand; CD137L; Cd157l; CDw137L; costimulatory molecule; homolog of mouse 4-1BB-L; Ly63l; receptor 4-1BB ligand; TNFRSF9; Tnfsf9; TNLG5A; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9 | |
Rabbit | |
Purified | |
RUO | |
8744 | |
4°C | |
Liquid |
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