Invitrogen™ CD137 Ligand (4-1BB Ligand) Recombinant Rabbit Monoclonal Antibody (BLR148J)

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA544483	Invitrogen™ MA544483	100 μL
PIMA544484	Invitrogen™ MA544484	20 μL

Description

CD137 Ligand (4-1BB Ligand) Recombinant Monoclonal Antibody for Western Blot

CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.

Specifications

• Antigen: CD137 Ligand (4-1BB Ligand)
• Concentration: 1000 μg/mL
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.09% sodium azide; pH 6.8-7.4
• Gene Accession No.: P41273
• Gene ID (Entrez): 8744
• Immunogen: Recombinant protein representing the extracellular domain of Human Tumor necrosis factor ligand superfamily member 9 (TNFSF9, aka 4-1BBL, CD137L; residues 71-254).
• Product Type: Antibody

• Clone: BLR148J
• Content And Storage: 4°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: TNFSF9
• Gene Alias: 4 1 BB Ligand; 4 1 BBL; 41BB Ligand; 4-1BB ligand; 41BBL; 4-1BBL; 4-1BB-L; AI848817; CD 137 Ligand; CD 137L; CD137 Ligand; CD137L; Cd157l; CDw137L; costimulatory molecule; homolog of mouse 4-1BB-L; Ly63l; receptor 4-1BB ligand; TNFRSF9; Tnfsf9; TNLG5A; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9
• Gene Symbols: TNFSF9
• Primary or Secondary: Primary
• Purification Method: Purified