CD1a Antibody (CB-T6), Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2452420.1MG

Catalog No. NBP24524201

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

CD1a Monoclonal specifically detects CD1a in Human, Mouse samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunofluorescence.

Specifications

• Antigen: CD1a
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunofluorescence 1 - 2 ug/ml
• Gene Alias: CD1, CD1a antigen, CD1A antigen, a polypeptide, CD1a molecule, cluster of differentiation 1 A, cortical thymocyte antigen CD1A, differentiation antigen CD1-alpha-3, epidermal dendritic cell marker CD1a, FCB6, HTA1, hTa1 thymocyte antigen, R4, T6, T-cell surface antigen T6/Leu-6, T-cell surface glycoprotein CD1a
• Host Species: Mouse
• Molecular Weight of Antigen: 49 kDa
• Quantity: 0.1 mg
• Research Discipline: Dendritic Cell Markers, Immunology
• Gene ID (Entrez): 909
• Target Species: Human, Mouse
• Form: Purified

• Applications: Flow Cytometry, Immunofluorescence
• Clone: CBT6
• Conjugate: Unconjugated
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Symbols: CD1A
• Immunogen: Human CD1a
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).
• Content And Storage: Store at 4C.
• Isotype: IgG1 κ

For Research Use Only