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CD20 Antibody (IGEL/1497R), PE, Novus Biologicals™
SDP

Catalog No. NB007603 Shop All R&D Systems Products
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NB007603 0.1 mL
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Catalog No. NB007603 Supplier Novus Biologicals Supplier No. NBP249873PE
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Description

Rabbit Monoclonal Antibody

CD20 Monoclonal specifically detects CD20 in Human samples. It is validated for Flow Cytometry.

Specifications

Antigen CD20
Applications Flow Cytometry
Classification Monoclonal
Clone IGEL/1497R
Conjugate PE
Dilution Flow Cytometry
Formulation PBS with 0.05% Sodium Azide
Gene Alias B1, B-lymphocyte antigen CD20, B-lymphocyte cell-surface antigen B1, B-lymphocyte surface antigen B1, Bp35MGC3969, CD20 antigen, CD20 receptor, CD20S7, CVID5, LEU-16, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, membrane-spanning 4-domains, subfamily A, member 1, MS4A2
Gene Symbols MS4A1
Host Species Rabbit
Immunogen Recombinant human full-length CD20 protein (Uniprot: P11836)
Purification Method Protein A purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Adaptive Immunity, B Cell Development and Differentiation Markers, Cancer, Cancer Stem Cells, Cell Biology, Cytokine Research, Immunology, Signal Transduction, Stem Cell Markers, Tumor Biomarkers
Primary or Secondary Primary
Test Specificity Recognizes a protein of 30-33kDa, which is identified as CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This monoclonal antibody can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkins disease, particularly of lymphocyte predominant type.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG
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