CD20 Antibody (SPM618) - IHC-Prediluted, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP248336

Catalog No. NBP248336

Description

CD20 Monoclonal specifically detects CD20 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: CD20
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Symbols: MS4A1
• Immunogen: Recombinant human CD20 protein (Uniprot: P11836)
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes a protein of 30-33kDa, which is identified as CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This monoclonal antibody can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin s disease, particularly of lymphocyte predominant type.
• Content And Storage: Store at 4C.
• Isotype: IgG2a κ

• Applications: Immunohistochemistry (Paraffin)
• Clone: SPM618
• Dilution: Immunohistochemistry-Paraffin
• Gene Alias: B1, B-lymphocyte antigen CD20, B-lymphocyte cell-surface antigen B1, B-lymphocyte surface antigen B1, Bp35MGC3969, CD20 antigen, CD20 receptor, CD20S7, CVID5, LEU-16, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, membrane-spanning 4-domains, subfamily A, member 1, MS4A2
• Host Species: Mouse
• Molecular Weight of Antigen: 35 kDa
• Quantity: 7 mL
• Research Discipline: Adaptive Immunity, B Cell Development and Differentiation Markers, Cancer, Cancer Stem Cells, Cell Biology, Cytokine Research, Immunology, Signal Transduction, Stem Cell Markers, Tumor Biomarkers
• Gene ID (Entrez): 931
• Target Species: Human
• Form: Purified