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CD21 Antibody (CR2/1952), Alexa Fluor™ 350, Novus Biologicals™
SDP

Catalog No. NB008519 Shop All R&D Systems Products
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NB008519 0.1 mL
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Catalog No. NB008519 Supplier Novus Biologicals Supplier No. NBP260733AF350
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Description

Mouse Monoclonal Antibody

CD21 Monoclonal specifically detects CD21 in Human samples. It is validated for ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen CD21
Applications Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone CR2/1952
Conjugate Alexa Fluor 350
Dilution Immunohistochemistry, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias C3DRSLEB9, CD21, CD21 antigen, Complement C3d receptor, complement component (3d/Epstein Barr virus) receptor 2, complement receptor type 2, Cr2, EBV receptor, Epstein-Barr virus receptor
Gene Symbols CR2
Host Species Mouse
Immunogen Recombinant fragment (around aa 44-196) of human CR2 (CD21) protein (exact sequence is proprietary) (Uniprot: P20023)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Adaptive Immunity, Apoptosis, B Cell Development and Differentiation Markers, Dendritic Cell Markers, Immunology
Primary or Secondary Primary
Test Specificity Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2)/ CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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