CD21 Antibody (CR2/1952) - Azide and BSA Free, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2607330.2MG

Catalog No. NBP26073302

Description

CD21 Monoclonal antibody specifically detects CD21 in Human samples. It is validated for Immunohistochemistry-Paraffin.

Specifications

• Antigen: CD21
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Dilution: Immunohistochemistry-Paraffin 1-2 ug/ml
• Gene Accession No.: P20023
• Gene Symbols: CR2
• Immunogen: Recombinant human CR2 (CD21) protein fragment (around aa 44-196) (exact sequence is proprietary)
• Purification Method: Protein A or G purified
• Research Discipline: Adaptive Immunity, Dendritic Cell Markers, Immunology
• Gene ID (Entrez): 1380
• Target Species: Human
• Form: Purified

• Applications: Immunohistochemistry (Paraffin)
• Clone: CR2/1952
• Conjugate: Unconjugated
• Formulation: 10mM PBS with No Preservative
• Gene Alias: C3DRSLEB9, CD21, CD21 antigen, Complement C3d receptor, complement component (3d/Epstein Barr virus) receptor 2, complement receptor type 2, Cr2, EBV receptor, Epstein-Barr virus receptor
• Host Species: Mouse
• Molecular Weight of Antigen: 140 kDa
• Quantity: 0.2 mg
• Primary or Secondary: Primary
• Test Specificity: Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2)/ CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
• Content And Storage: Store at 4°C.
• Isotype: IgG1 κ