CD21 Antibody (CR2/1952) - Azide and BSA Free, Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP26073301	Novus Biologicals NBP2607330.1MG	0.1 mg
NBP26073302	Novus Biologicals NBP2607330.2MG	0.2 mg

Description

CD21 Monoclonal specifically detects CD21 in Human samples. It is validated for ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.

Specifications

• Antigen: CD21
• Concentration: 1 mg/mL
• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: P20023
• Gene ID (Entrez): 1380
• Immunogen: Recombinant human CR2 (CD21) protein fragment (around aa 44-196) (exact sequence is proprietary)
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C.
• Molecular Weight of Antigen: 140 kDa

• Clone: CR2/1952
• Dilution: Immunohistochemistry-Paraffin 1-2 ug/ml
• Classification: Monoclonal
• Form: Purified
• Research Discipline: Adaptive Immunity, Dendritic Cell Markers, Immunology
• Formulation: 10mM PBS with No Preservative
• Gene Alias: C3DRSLEB9, CD21, CD21 antigen, Complement C3d receptor, complement component (3d/Epstein Barr virus) receptor 2, complement receptor type 2, Cr2, EBV receptor, Epstein-Barr virus receptor
• Gene Symbols: CR2
• Isotype: IgG1 κ
• Purification Method: Protein A or G purified
• Test Specificity: Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2)/ CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.