CD21 Antibody (CR2/1952), DyLight 755, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP260733IR

Catalog No. NB008534

Description

CD21 Monoclonal specifically detects CD21 in Human samples. It is validated for ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: CD21
• Classification: Monoclonal
• Conjugate: DyLight 755
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Symbols: CR2
• Immunogen: Recombinant fragment (around aa 44-196) of human CR2 (CD21) protein (exact sequence is proprietary) (Uniprot: P20023)
• Quantity: 0.1 mL
• Research Discipline: Adaptive Immunity, Apoptosis, B Cell Development and Differentiation Markers, Dendritic Cell Markers, Immunology
• Test Specificity: Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2)/ CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
• Content And Storage: Store at 4°C in the dark.

• Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
• Clone: CR2/1952
• Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
• Gene Alias: C3DRSLEB9, CD21, CD21 antigen, Complement C3d receptor, complement component (3d/Epstein Barr virus) receptor 2, complement receptor type 2, Cr2, EBV receptor, Epstein-Barr virus receptor
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Isotype: IgG1 κ