Learn More
CD279 Hamster anti-Mouse, PE, Clone: J43, BD
Hamster Monoclonal Antibody
$104.00 - $313.50
Specifications
Antigen | CD279 |
---|---|
Clone | J43 |
Concentration | 0.2mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Description
The J43 antibody reacts with CD279 (PD-1), a 50-55-kDa glycoprotein encoded by the Pdcd1 gene of the CD28 family of the Ig superfamily. The expression of Pdcd1 mRNA and PD-1 protein is tightly regulated. PD-1 is transiently expressed on CD4-CD8thymocytes, it is upregulated on some cell lines upon induction of apoptosis, it is induced on thymocytes and splenic T and B lymphocytes after stimulation through their antigen receptors, and it is induced on activated myeloid cells. In addition, Pdcd1 mRNA is transiently expressed in developing B lymphocytes at the pro-B-cell stage. The presence of an ITIM (Immunoreceptor nhibitory Motif) on PD-1's intracytoplasmic region and the development of splenomegaly and breakdown of peripheral tolerance in PD-1[-/-] mice suggest that PD-1 may be involved in the negative regulation of immune responses. The PD-1 ligands, B7-H1 (also known as PD-L1) and B7-DC (PD-L2), are members of the B7 family of the Ig superfamily. The J43 antibody blocks the binding of PD-1 to its two ligands.
Specifications
CD279 | |
0.2mg/mL | |
Monoclonal | |
Hamster | |
Mouse | |
Syrian Hamster kidney cell line BKH transfected with Pdcd1 cDNA | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
J43 | |
Flow Cytometry | |
PE | |
RUO | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
IgG2 κ | |
Affinity Purified | |
PD-1 |
For Research Use Only.
Your input is important to us. Please complete this form to provide feedback related to the content on this product.