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CD279 Hamster anti-Mouse, PE, Clone: J43, BD

Hamster Monoclonal Antibody

$104.00 - $313.50

Specifications

Antigen CD279
Clone J43
Concentration 0.2mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB561788
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BD Biosciences
561788
25 μg
Each for $104.00
Only null left
Add to Cart
 
BDB551892
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BD Biosciences
551892
0.1 mg
Each for $313.50
Only null left
Add to Cart
 
Description

Description

The J43 antibody reacts with CD279 (PD-1), a 50-55-kDa glycoprotein encoded by the Pdcd1 gene of the CD28 family of the Ig superfamily. The expression of Pdcd1 mRNA and PD-1 protein is tightly regulated. PD-1 is transiently expressed on CD4-CD8thymocytes, it is upregulated on some cell lines upon induction of apoptosis, it is induced on thymocytes and splenic T and B lymphocytes after stimulation through their antigen receptors, and it is induced on activated myeloid cells. In addition, Pdcd1 mRNA is transiently expressed in developing B lymphocytes at the pro-B-cell stage. The presence of an ITIM (Immunoreceptor nhibitory Motif) on PD-1's intracytoplasmic region and the development of splenomegaly and breakdown of peripheral tolerance in PD-1[-/-] mice suggest that PD-1 may be involved in the negative regulation of immune responses. The PD-1 ligands, B7-H1 (also known as PD-L1) and B7-DC (PD-L2), are members of the B7 family of the Ig superfamily. The J43 antibody blocks the binding of PD-1 to its two ligands.

Specifications

Specifications

CD279
0.2mg/mL
Monoclonal
Hamster
Mouse
Syrian Hamster kidney cell line BKH transfected with Pdcd1 cDNA
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
J43
Flow Cytometry
PE
RUO
Aqueous buffered solution containing ≤0.09% sodium azide.
IgG2 κ
Affinity Purified
PD-1
Videos
SDS
Documents

Documents

Product Certifications

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