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Invitrogen™ CD303a Monoclonal Antibody (201A), APC, eBioscience™
Mouse Monoclonal Antibody
Supplier: Invitrogen™ 17981842

Description
Description: This 201A monoclonal antibody reacts with human CD303a, which is also known as CLEC4C or Blood Dendritic Cell Antigen 2 (BDCA-2). This type II transmembrane protein is expressed almost exclusively on plasmacytoid dendritic cells, which secrete type I interferon during antiviral and antitumor responses. Studies have demonstrated that CD303a binds asialo-galactosyl-oligosaccharides on invading pathogens, resulting in the activation of signaling pathways that lead to CD303a internalization and downregulation of interferon production. Applications Reported: This 201A antibody has been reported for use in flow cytometric analysis. Applications Tested: This 201A antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.
This gene encodes a member of the C-type lectin/C-type lectin-like domain superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene.
Specifications
CD303a | |
Monoclonal | |
5 μL/Test | |
PBS with BSA and 0.09% sodium azide; pH 7.2 | |
Q8WTT0 | |
CLEC4C | |
Affinity chromatography | |
RUO | |
170482 | |
4°C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
201A | |
APC | |
CLEC4C | |
BDCA2; BDCA-2; Blood dendritic cell antigen 2; blood dendritic cell antigen 2 protein; CD303; CD303 antigen; CLEC4C; CLECSF11; CLECSF7; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 7; C-type lectin domain family 4 member C; C-type lectin domain family 4, member C; C-type lectin domain family 4, member C, isoform 1; C-type lectin superfamily member 7; dendritic cell lectin b; dendritic lectin; DLEC; HECL; PRO34150; UNQ9361/PRO34150 | |
Mouse | |
100 Tests | |
Primary | |
Human | |
Antibody | |
IgG2a κ |
Safety and Handling
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