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CD35 Antibody (E11) - Azide and BSA Free, Novus Biologicals™
SDP

Catalog No. NBP233080 Shop All R&D Systems Products
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NBP233080 0.1 mg
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Catalog No. NBP233080 Supplier Novus Biologicals Supplier No. NBP233080
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Description

Mouse Monoclonal Antibody

CD35 Monoclonal specifically detects CD35 in Human, Monkey, Baboon, Cynomolgus Monkey, Rhesus Macaque samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

Antigen CD35
Applications ELISA
Classification Monoclonal
Clone E11
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution ELISA 1-5ug/ml for coating
Gene Alias complement component (3b/4b) receptor 1 (Knops blood group), KN
Gene Symbols CR1
Host Species Mouse
Immunogen Intact human monocytes were used as immunogen to generate the CD35 antibody (Hogg et al, 1984).
Molecular Weight of Antigen 215 kDa
Purification Method Protein A or G purified
Quantity 0.1 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1378
Test Specificity Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This monoclonal antibody is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. This monoclonal antibody is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This monoclonal antibody labels follicular dendritic cells and follicular dendritic cell sarcoma.
Target Species Human, Monkey
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1 κ
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