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CD36 Antibody (185-1G2) - Azide and BSA Free, Novus Biologicals™
SDP

Catalog No. NB024689 Shop All R&D Systems Products
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NB024689 0.1 mg
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Catalog No. NB024689 Supplier Novus Biologicals Supplier No. NBP295271
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Description

Mouse Monoclonal Antibody

CD36 Monoclonal specifically detects CD36 in Human samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Functional, Immunofluorescence.

Specifications

Antigen CD36/SR-B3
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence
Classification Monoclonal
Clone 185-1G2
Concentration 1 mg/ml
Conjugate Unconjugated
Dilution Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunocytochemistry/Immunofluorescence 1-2 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
Formulation 10 mM PBS
Gene Alias CD36 antigen, CD36 molecule (thrombospondin receptor), FA6-152, FATCHDS7, Fatty acid translocase, Glycoprotein IIIb, GP3Bthrombospondin receptor), GPIIIB, Leukocyte differentiation antigen CD36, PAS IV, PAS-4, Platelet collagen receptor, platelet glycoprotein 4, Platelet glycoprotein IV, scavenger receptor class B, member 3, Thrombospondin receptor
Host Species Mouse
Immunogen Stimulated human leukocytes
Purification Method Protein A or G purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cancer, Cellular Markers, Endothelial Cell Markers, Hematopoietic Stem Cell Markers, Immunology, Lipid and Metabolism, Stem Cell Markers
Primary or Secondary Primary
Gene ID (Entrez) 948
Test Specificity Recognizes a protein of 80kDa-90kDa, identified as CD36 (Workshop IV; Code P-26). Its epitope maps between aa155-183. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36. This monoclonal antibody blocks adhesion of P. falciparum parasitized red blood cells to CD36 and strongly inhibits collagen-induced platelet aggregation.
Target Species Human
Content And Storage Store at 4°C.
Form Purified
Isotype IgG2a κ
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