Invitrogen™ CD368 (Clec6) Monoclonal Antibody (9B9), eFluor™ 660, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 50911342

Catalog No. 50-911-342

Description

This 9B9 MAb reacts with human CD368, also known as Clec6 or ClecsF8 or Clec4D. In peripheral blood, this C-type lectin is expressed highly on granulocytes and CD14+CD16- monocytes. Some dendritic cell populations also exhibit low levels of CD368 expression. Studies have demonstrated that this receptor undergoes endocytosis due to its C-type lectin-like domain. CD368 functions as a phagocytic receptor and is involved in proinflammatory cytokine production in cooperation with Toll-like receptors. Finally, CD368 also participates in cellular activation via signaling through Syk kinase.

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Specifications

• Antigen: CD368 (Clec6)
• Classification: Monoclonal
• Concentration: 5 μL/Test
• Formulation: PBS with BSA and 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q8WXI8
• Gene Symbols: CLEC4D
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 338339
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: 9B9
• Conjugate: eFluor 660
• Gene: CLEC4D
• Gene Alias: CD368; Clec4d; CLEC6; CLEC-6; CLECSF8; CLECSF8Mpcl; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 8; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8; C-type lectin domain family 4 member D; C-type lectin domain family 4, member d; C-type lectin receptor; C-type lectin superfamily member 8; C-type lectin, superfamily member 8; C-type lectin-like receptor 6; macrophage C-type lectin; macrophage-restricted C-type lectin; Mcl; MGC40078; Mpcl; superfamilymember 8
• Host Species: Mouse
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b κ

Safety and Handling

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