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CD40/TNFRSF5 Antibody (A54 scFv), DyLight 650, Novus Biologicals™
SDP

Catalog No. NB016100 Shop All R&D Systems Products
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NB016100 0.1 mL
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Catalog No. NB016100 Supplier Novus Biologicals Supplier No. NBP281101C
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Description

Rabbit Monoclonal Antibody

CD40/TNFRSF5 Monoclonal specifically detects CD40/TNFRSF5 in Human samples. It is validated for ELISA, Immunocytochemistry/Immunofluorescence.

Specifications

Antigen CD40/TNFRSF5
Applications ELISA, Immunocytochemistry, Immunofluorescence
Classification Monoclonal
Clone A54 scFv
Conjugate DyLight 650
Dilution ELISA, Immunocytochemistry/Immunofluorescence
Formulation 50mM Sodium Borate
Gene Alias B cell surface antigen CD40, B-cell surface antigen CD40, Bp50B cell-associated molecule, CD40 antigen, CD40 molecule, TNF receptor superfamily member 5, CD40 type II isoform, CD40L receptor, CDw40, MGC9013, nerve growth factor receptor-related B-lymphocyte activation molecule, p50, TNFRSF5CD40 antigen (TNF receptor superfamily member 5), tumor necrosis factor receptor superfamily member 5, tumor necrosis factor receptor superfamily, member 5
Gene Symbols CD40
Host Species Rabbit
Immunogen A54 human anti-CD40/TNFRSF5 scFv was selected from the n-CoDeR phage display library after 4 rounds of selections using biotinylated CD40-Fcgamma fusion protein as bait and subsequent capture of bound phages on streptavidin-caoted magnetic beads.
Purification Method Protein A purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Adaptive Immunity, Apoptosis, Asthma, B Cell Development and Differentiation Markers, Cancer, Hematopoietic Stem Cell Markers, Immunology, Signal Transduction, Stem Cell Markers
Primary or Secondary Primary
Gene ID (Entrez) 958
Test Specificity A54 binds specifically to the D1 domain of CD40/TNFRSF5 (and can only bind to the intact i.e. non-truncated version of CD40/TNFRSF5 and when an AD2 peptide tag has not been added) and can recognize CD40/TNFRSF5 on a B cell line (BJAB). This scFv binds to CD40/TNFRSF5 (immobilized by amine coupling) with a KD within the range of 40nM. CD40/TNFRSF5 is a glycoprotein of the TNFR superfamily and is expressed on all mature B cells, dendritic cells, activated monocytes, some endothelial cells and some epithelium including the thymus. CD40/TNFRSF5 binds to the membrane protein CD154 of the TNF superfamily and this interaction is required for the seconfary immune responses and germinal centre formation.
Target Species Human
Content And Storage Store at 4°C in the dark.
Form Purified
Isotype IgG λ
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