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CD43 Monoclonal Antibody (4-29-5-10-21), PerCP-eFluor™ 710, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

$143.00 - $375.00

Specifications

Antigen CD43
Clone 4-29-5-10-21
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-113-0751
Encompass_Preferred
View Documents
Invitrogen™
46043841
25 Tests
Each for $143.00
Only null left
Edge
Add to Cart
 
50-113-0752
Encompass_Preferred
View Documents
Invitrogen™
46043842
100 Tests
Each for $375.00
Only null left
Add to Cart
 
Description

Description

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumour suppressor p53 protein, but in case of p53 and ARF defficiency CD43 promotes tumour proliferation and viability. It appears to be an important modulator of leukocyte functions.

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability. CD43 appears to be an important modulator of leukocyte functions. Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.
Specifications

Specifications

CD43
5 μL/Test
Monoclonal
Liquid
RUO
PBS with BSA and 0.09% sodium azide; pH 7.2
3E8 antigen; A630014B01Rik; B-cell differentiation antigen LP-3; CD43; CD43 cytoplasmic tail; CD43-ct; Galactoglycoprotein; GALGP; gpL115; Leukocyte sialoglycoprotein; leukosialin; leukosianin; LOC101120462; LOW QUALITY PROTEIN: leukosialin; Lsn; Lsn1; Ly48; Ly-48; Lymphocyte antigen 48; sialophorin; sialophorin (gpL115, leukosialin, CD43); sialophorin gpL115; SPN; W3/13 antigen
SPN
Primary
4°C, store in dark, DO NOT FREEZE!
SPN
4-29-5-10-21
Flow Cytometry
PerCP-eFluor 710
Mouse
Human, Monkey
P16150
6693
IgG1 κ
Affinity Chromatography
Antibody
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only.

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