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CD45RA Antibody (PTPRC/1131) - IHC-Prediluted, Novus Biologicals™
SDP

Catalog No. NBP248450 Shop All R&D Systems Products
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NBP248450 7 mL
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Catalog No. NBP248450 Supplier Novus Biologicals Supplier No. NBP248450
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Description

Mouse Monoclonal Antibody

CD45RA Monoclonal specifically detects CD45RA in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen CD45RA
Applications Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone PTPRC/1131
Conjugate Unconjugated
Dilution Immunohistochemistry, Immunohistochemistry-Paraffin
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias B220, CD45 antigen, CD45R, EC 3.1.3.48, L-CA, LY5, protein tyrosine phosphatase, receptor type, C, receptor-type tyrosine-protein phosphatase C, T200 glycoprotein, T200 leukocyte common antigen, T200receptor type, c polypeptide
Gene Symbols PTPRC
Host Species Mouse
Immunogen Recombinant full-length human CD45RA protein
Purification Method Protein A or G purified
Quantity 7 mL
Regulatory Status RUO
Research Discipline Adaptive Immunity, Cell Biology, Cellular Markers, Cytokine Research, Hematopoietic Stem Cell Markers, Immunology, Mesenchymal Stem Cell Markers, Microglia Markers, Neuronal Cell Markers, Neuroscience, Signal Transduction, Stem Cell Markers
Primary or Secondary Primary
Gene ID (Entrez) 5788
Test Specificity Recognizes a protein of 205kDa-220kDa, identified as CD45RA. CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This monoclonal antibody is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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