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CD46 Antibody (122.2), Alexa Fluor™ 532, Novus Biologicals™
SDP

Catalog No. NP23319A32 Shop All R&D Systems Products
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NP23319A32 0.1 mL
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Catalog No. NP23319A32 Supplier Novus Biologicals Supplier No. NBP233159AF532
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Description

Mouse Monoclonal Antibody

CD46 Monoclonal specifically detects CD46 in Human samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence.

Specifications

Antigen CD46
Applications Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone 122.2
Conjugate Alexa Fluor 532
Dilution Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias AHUS2, CD46 antigen, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MIC10, TLXcomplement regulatory protein, trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen
Gene Symbols CD46
Host Species Mouse
Immunogen Recombinant human CD46 protein (Uniprot: P15529)
Purification Method Protein A or G purified
Quantity 0.1 mL
Primary or Secondary Primary
Gene ID (Entrez) 4179
Test Specificity CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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