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CD46 Antibody (122.2), Novus Biologicals™
SDP

Catalog No. NBP2252222M Shop All R&D Systems Products
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0.2 mg
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NBP2252222M 0.2 mg
NBP22522202 0.02 mg
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Catalog No. NBP2252222M Supplier Novus Biologicals Supplier No. NBP2252220.2MG

Description

Mouse Monoclonal Antibody

CD46 Monoclonal antibody specifically detects CD46 in Human samples. It is validated for Flow Cytometry, SDS-Page, Immunofluorescence.

Specifications

Antigen CD46
Applications Flow Cytometry, SDS-Page, Immunofluorescence
Classification Monoclonal
Clone 122.2
Concentration 0.2mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry 0.5-1ug/million cells in 0.1ml, SDS-Page, Immunofluorescence 0.5-1ug/ml
Formulation PBS with 0.05% BSA. with 0.05% Sodium Azide
Gene Accession No. NP_002380
Gene Alias AHUS2, CD46 antigen, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MIC10, TLXcomplement regulatory protein, trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen
Gene Symbols CD46
Host Species Mouse
Immunogen A recombinant protein fragment specific for human CD46 was used as the immunogen.
Purification Method Protein G purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Cancer, Cell Biology, Cellular Markers, Immunology
Primary or Secondary Primary
Gene ID (Entrez) 4179
Test Specificity CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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For Research Use Only

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