Invitrogen™ CD46 Polyclonal Antibody

Catalog No.	Quantity
PIPA597563	100 μg

Catalog No. PIPA597563

Supplier: Invitrogen™ PA597563

Description

Rabbit Polyclonal Antibody

CD46 Polyclonal Antibody for Western Blot, IHC (P), ELISA

CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.

Specifications

• Antigen: CD46
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1.75 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene: CD46
• Gene Accession No.: O88174, P15529
• Gene Alias: AHUS2; antigen identified by monoclonal antibody TRA-2-10; brain microvascular membrane cofactor; brain microvascular membrane cofactor protein CD46; Cd46; CD46 antigen, complement regulatory protein; CD46 complement regulatory protein; CD46 molecule; CD46 molecule, complement regulatory protein; CD46 splice variant; complement membrane cofactor protein; complement regulatory protein; Mcp; MCP; complement activation regulator; measles virus receptor; membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); membrane cofactor protein variant 10; membrane cofactor protein variant 7; membrane cofactor protein variant 8; membrane cofactor protein variant 9; MGC26544; MIC10; soluble membrane cofactor protein variant 11; soluble membrane cofactor protein variant 12; soluble membrane cofactor protein variant 13; TLX; TRA2.10; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
• Gene Symbols: CD46
• Host Species: Rabbit
• Immunogen: Recombinant Human Membrane cofactor protein (164-325AA).
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 17221, 4179
• Target Species: Human, Mouse
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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