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CD5 Antibody (CD5/54/F6), DyLight 350, Novus Biologicals™
SDP

Catalog No. NBP234593UV Shop All R&D Systems Products
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Catalog No. NBP234593UV Supplier Novus Biologicals Supplier No. NBP234593UV
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Description

Mouse Monoclonal Antibody

CD5 Monoclonal specifically detects CD5 in Human, Rat, Porcine, Bovine, Chicken, Equine, Guinea Pig, Monkey, Rabbit samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen CD5
Applications Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Classification Monoclonal
Clone CD5/54/F6
Conjugate DyLight 350
Dilution Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Gene Alias CD5 antigen, CD5 antigen (p56-62), CD5 molecule, LEU1T-cell surface glycoprotein CD5, Lymphocyte antigen T1/Leu-1, T1
Gene Symbols CD5
Host Species Mouse
Immunogen Recombinant fragment (around aa450-495) of human CD5 protein (intracellular region). (Uniprot: P06127 )
Molecular Weight of Antigen 67 kDa
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Adaptive Immunity, Cell Biology, Cytokine Research, Immunology
Primary or Secondary Primary
Gene ID (Entrez) 921
Test Specificity Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (∼10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.
Target Species Human, Rat, Pig, Bovine, Chicken, Equine, Guinea Pig, Monkey, Rabbit
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG1 κ
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