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CD5 Antibody (CD5/54/F6), FITC, Novus Biologicals™
SDP

Catalog No. NB006202 Shop All R&D Systems Products
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NB006202 0.1 mL
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Catalog No. NB006202 Supplier Novus Biologicals Supplier No. NBP234593F
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Description

Mouse Monoclonal Antibody

CD5 Monoclonal specifically detects CD5 in Human, Rat, Porcine, Bovine, Chicken, Equine, Guinea Pig, Monkey, Rabbit samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen CD5
Applications Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone CD5/54/F6
Conjugate FITC
Dilution Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Formulation PBS with 0.05% Sodium Azide
Gene Alias CD5 antigen, CD5 antigen (p56-62), CD5 molecule, LEU1T-cell surface glycoprotein CD5, Lymphocyte antigen T1/Leu-1, T1
Gene Symbols CD5
Host Species Mouse
Immunogen Recombinant fragment (around aa450-495) of human CD5 protein (intracellular region). (Uniprot: P06127 )
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Adaptive Immunity, B Cell Development and Differentiation Markers, Cell Biology, Cytokine Research, Immunology, Phospho Specific
Primary or Secondary Primary
Test Specificity Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (∽10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.
Target Species Human, Rat, Pig, Bovine, Canine, Chicken, Equine, Guinea Pig, Monkey, Rabbit
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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