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CD53 Antibody (161-2), Alexa Fluor™ 532, Novus Biologicals™
SDP

Catalog No. NP24789A32 Shop All R&D Systems Products
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NP24789A32 0.1 mL
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Catalog No. NP24789A32 Supplier Novus Biologicals Supplier No. NBP247859AF532
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Description

Mouse Monoclonal Antibody

CD53 Monoclonal specifically detects CD53 in Human, Baboon (Negative), Equine (Negative) samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunofluorescence.

Specifications

Antigen CD53
Applications Flow Cytometry, Immunofluorescence
Classification Monoclonal
Clone 161-2
Conjugate Alexa Fluor 532
Dilution Flow Cytometry, Immunofluorescence
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias antigen MOX44 identified by monoclonal MRC-OX44, CD53 antigentetraspanin-25, CD53 glycoprotein, CD53 molecule, CD53 tetraspan antigen, cell surface antigen, Cell surface glycoprotein CD53, MOX44transmembrane glycoprotein, Tetraspanin-25, tspan-25, TSPAN25leukocyte surface antigen CD53
Gene Symbols CD53
Host Species Mouse
Immunogen Stimulated human leukocytes
Quantity 0.1 mL
Primary or Secondary Primary
Gene ID (Entrez) 963
Test Specificity Recognizes a protein of 33-55kDa, identified as CD53 (Workshop VI; Code N-L033). It is expressed on monocytes and macrophages, dendritic cells, osteoblasts and osteoclasts, and on T and B cells from every stage of differentiation but is absent from platelets, red blood cells. CD53 appears to be the marker with widest reactivity as well as the marker with the strictest specificity to hematopoietic cells. CD53 is a type III membrane with both termini in the cytoplasm and two loops in the extracellular environment. This molecule, in common with other members of tetraspan family, is involved in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. CD53 crosslinking induces calcium flux on human monocyte and B cells. Cross-linking of CD53 promotes activation of resting human B-lymphocytes. This monoclonal antibody recognizes CD53 transfected cells and partially inhibits T-cell proliferation induced by CD3 antibody (clone: UCHT1).
Target Species Human, Baboon, Equine
Content And Storage Store at 4°C in the dark.
Isotype IgG2a κ
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