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CD53 Antibody (161-2), Novus Biologicals™
SDP

Catalog No. NBP24460900 Shop All R&D Systems Products
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NBP24460900 0.02 mg
NBP24460901 0.1 mg
NBP24460902 0.2 mg
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Catalog No. NBP24460900 Supplier Novus Biologicals Supplier No. NBP2446090.02MG
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Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

CD53 Monoclonal specifically detects CD53 in Human, Baboon (Negative), Equine (Negative) samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Functional, Immunofluorescence.

Specifications

Antigen CD53
Applications Flow Cytometry, SDS-Page, Immunofluorescence
Classification Monoclonal
Clone 161-2
Concentration 0.2 mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Accession No. P19397
Gene Alias antigen MOX44 identified by monoclonal MRC-OX44, CD53 antigentetraspanin-25, CD53 glycoprotein, CD53 molecule, CD53 tetraspan antigen, cell surface antigen, Cell surface glycoprotein CD53, MOX44transmembrane glycoprotein, Tetraspanin-25, tspan-25, TSPAN25leukocyte surface antigen CD53
Gene Symbols CD53
Host Species Mouse
Immunogen Stimulated human leukocytes
Purification Method Protein A or G purified
Quantity 0.02 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Gene ID (Entrez) 963
Test Specificity Recognizes a protein of 33-55kDa, identified as CD53 (Workshop VI; Code N-L033). It is expressed on monocytes and macrophages, dendritic cells, osteoblasts and osteoclasts, and on T and B cells from every stage of differentiation but is absent from platelets, red blood cells. CD53 appears to be the marker with widest reactivity as well as the marker with the strictest specificity to hematopoietic cells. CD53 is a type III membrane with both termini in the cytoplasm and two loops in the extracellular environment. This molecule, in common with other members of tetraspan family, is involved in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. CD53 crosslinking induces calcium flux on human monocyte and B cells. Cross-linking of CD53 promotes activation of resting human B-lymphocytes. This MAb recognizes CD53 transfected cells and partially inhibits T-cell proliferation induced by CD3 antibody (clone: UCHT1).
Target Species Human, Baboon (Negative), Equine (Negative)
Content And Storage Store at 4C.
Form Purified
Isotype IgG2a κ
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For Research Use Only

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