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CD74 Antibody (CLIP/813) - IHC-Prediluted, Novus Biologicals™
SDP

Catalog No. NBP248026 Shop All R&D Systems Products
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NBP248026 7 mL
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Catalog No. NBP248026 Supplier Novus Biologicals Supplier No. NBP248026
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Description

Mouse Monoclonal Antibody

CD74 Monoclonal specifically detects CD74 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen CD74
Applications Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone CLIP/813
Conjugate Unconjugated
Dilution Immunohistochemistry, Immunohistochemistry-Paraffin
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias CD74 antigen, CD74 antigen (invariant polypeptide of major histocompatibility complex, classII antigen-associated), CD74 molecule, major histocompatibility complex, class II invariant chain, DHLAGgamma chain of class II antigens, HLA class II histocompatibility antigen gamma chain, HLADG, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, Ia antigen-associated invariant chain, Ia-associated invariant chain, Ia-GAMMA, Ii, MHC HLA-DR gamma chain, p33
Gene Symbols CD74
Host Species Mouse
Immunogen Recombinant full-length human CD74 protein (Uniprot: P044233)
Purification Method Protein A or G purified
Quantity 7 mL
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Gene ID (Entrez) 972
Test Specificity It recognizes a protein of ∼35kDa, identified as CD74. It is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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